Ruiz Rueda Lab describes the metabolic role of a molecular pump that helps E. coli resist antibiotics

A new publication by the Ruiz Rueda lab identifies the global role of the AcrAB-TolC multidrug efflux pump of Escherichia coli in cell metabolism. This study is authored by former microbiology undergraduate students Allea Cauilan (also a BUILD PODER and Presidential scholar) and Karen Ramos, Lecturer Dana Harmon, and Assistant Professor Cristian Ruiz Rueda, and was recently published in the International Journal of Antimicrobial Agents. By determining how the AcrAB–TolC efflux pump and its transcriptional regulator AcrR impact cell metabolism at a global scale, this study provides a new understanding of how this important pump contributes to antibiotic resistance, metabolism and cell physiology in E. coli.